U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Icos inducible T-cell co-stimulator [ Rattus norvegicus (Norway rat) ]

Gene ID: 64545, updated on 10-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
Icosprovided by RGD
Official Full Name
inducible T-cell co-stimulatorprovided by RGD
Primary source
RGD:620123
See related
EnsemblRapid:ENSRNOG00000046196 AllianceGenome:RGD:620123
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ailim
Summary
Involved in T cell costimulation; T cell tolerance induction; and cell-cell adhesion. Predicted to be located in external side of plasma membrane. Predicted to be integral component of plasma membrane. Used to study myocarditis. Biomarker of colitis and uveitis. Human ortholog(s) of this gene implicated in celiac disease; common variable immunodeficiency; and immunoglobulin alpha deficiency. Orthologous to human ICOS (inducible T cell costimulator). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 162.0), Spleen (RPKM 50.6) and 2 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Icos in Genome Data Viewer
Location:
9q32
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (69862042..69900864)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (62368075..62406900)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (67748157..67786808)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene Cd28 molecule Neighboring gene cytotoxic T-lymphocyte-associated protein 4 Neighboring gene proteasome 20S subunit alpha 7, pseudogene 3 Neighboring gene uncharacterized LOC108351940

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Effect of siRNA silencing of inducible co-stimulatory molecule on myocardial cell hypertrophy after cardiac infarction in rats. Wang WM, et al. Genet Mol Res, 2016 May 20. PMID 27323062
  2. Effect of Inducible Co-Stimulatory Molecule siRNA in Cerebral Infarction Rat Models. Luo Y, et al. Med Sci Monit, 2015 Oct 5. PMID 26436531, Free PMC Article
  3. Increased production of interleukin-17 over interleukin-10 by treg cells implicates inducible costimulator molecule in experimental spondyloarthritis. Araujo LM, et al. Arthritis Rheumatol, 2014 Sep. PMID 24909668
  4. Inducible co-stimulator (ICOS) is upregulated in experimental autoimmune uveoretinitis. Xing L, et al. Graefes Arch Clin Exp Ophthalmol, 2006 Dec. PMID 16601981
  5. Inhibition of chronic rejection and development of tolerogenic T cells after ICOS-ICOSL and CD40-CD40L co-stimulation blockade. Guillonneau C, et al. Transplantation, 2005 Aug 27. PMID 16220623

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the increased expression of ICOS/ICOS ligand in periapical lesions was associated with the inflammatory infiltration and alveolar bone destruction of apical periodontitis
    Title: Association between Increased Inducible Costimulator/Inducible Costimulator Ligand Expression with Bone Destruction in Apical Periodontitis.
  2. ICOS-targeted siRNA can effectively silence gene expression of ICOS, and provided satisfactory treatment efficacy for myocardial cell hypertrophy after infarction.
    Title: Effect of siRNA silencing of inducible co-stimulatory molecule on myocardial cell hypertrophy after cardiac infarction in rats.
  3. ICOS siRNA can protect brain tissues from ischemia injuries after cerebral infarction, improve limb movement and coordination, lower the mortality rate of rats, and inhibit T cell-induced cytokines
    Title: Effect of Inducible Co-Stimulatory Molecule siRNA in Cerebral Infarction Rat Models.
  4. our data highlight a key role for ICOS signaling in the generation of imbalanced production of IL-10 and IL-17 by Treg cells in a rat model of spondyloarthritis.
    Title: Increased production of interleukin-17 over interleukin-10 by treg cells implicates inducible costimulator molecule in experimental spondyloarthritis.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in T cell costimulation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in T cell costimulation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in T cell costimulation IEA
Inferred from Electronic Annotation
more info
  
involved_in T cell tolerance induction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in T cell tolerance induction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
inducible T-cell costimulator
Names
activation-inducible lymphocyte immunomediatory molecule

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001431817.1 → NP_001418746.1  inducible T-cell costimulator isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009

  2. NM_001431818.1 → NP_001418747.1  inducible T-cell costimulator isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    Q9R1T7, Q9WVR9
    UniProtKB/TrEMBL
    A6IPD8

  3. NM_001431819.1 → NP_001418748.1  inducible T-cell costimulator isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009

  4. NM_022610.3 → NP_072132.1  inducible T-cell costimulator isoform 1 precursor

    See identical proteins and their annotated locations for NP_072132.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    Q9R1T7, Q9WVR9
    UniProtKB/TrEMBL
    A0A0G2JZC0, A6IPD8
    Related
    ENSRNOP00000064455.1, ENSRNOT00000071226.4
    Conserved Domains (1) summary
    pfam15910
    Location:23 → 135
    V-set_2; ICOS V-set domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    69862042..69900864
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008767136.4 → XP_008765358.1  inducible T-cell costimulator isoform X1

    See identical proteins and their annotated locations for XP_008765358.1

    UniProtKB/TrEMBL
    A0A8I5ZN49, A6IPD9
    Conserved Domains (1) summary
    pfam15910
    Location:23 → 135
    V-set_2; ICOS V-set domain

  2. XM_006245038.5 → XP_006245100.1  inducible T-cell costimulator isoform X2

    Conserved Domains (1) summary
    pfam15910
    Location:23 → 135
    V-set_2; ICOS V-set domain

  3. XM_039084171.1 → XP_038940099.1  inducible T-cell costimulator isoform X4

    Conserved Domains (1) summary
    cl11960
    Location:21 → 58
    Ig; Immunoglobulin domain

  4. XM_006245037.5 → XP_006245099.1  inducible T-cell costimulator isoform X1

    See identical proteins and their annotated locations for XP_006245099.1

    UniProtKB/TrEMBL
    A0A8I5ZN49, A6IPD9
    Related
    ENSRNOP00000079452.1, ENSRNOT00000119869.2
    Conserved Domains (1) summary
    pfam15910
    Location:23 → 135
    V-set_2; ICOS V-set domain

  5. XM_063267687.1 → XP_063123757.1  inducible T-cell costimulator isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R1T7.1 GenPept UniProtKB/Swiss-Prot:Q9R1T7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous